A systematic review on the current radiogenomics studies in glioblastomas

Sotirios Bisdas, Evangelia Ioannidou, Felice D'Arco


Glioblastomas (GBM) have one of the poorest prognoses of any cancer. Current cutting-edge research aims to pave the way for new non-invasive methods of diagnosing brain tumours through innovative imaging techniques and genomic information from tumour samples. Over the past few years, various whole genome sequencing analysis has identified biomarkers and thus gradually changed the way of diagnosing brain tumours. In this context, MRI is a versatile imaging technique as it can provide multifaceted information derived from both morphologic and functional imaging biomarkers (radiomics) in brain. Radiogenomics is attempting to probe any correlation between radiological and histological features and hopefully assess the physiological heterogeneity and genetic alterations paving the way to a holistic approach of the tumour metabolic, pathophysiological and structural fingerprint.  This systematic review aims to summarise the current published evidence of radiogenomics in GBM and also raise awareness for future research in this field.


Glioblastoma; Radiomics; Genomics; Biomarkers; Review; MR imaging

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DOI: http://dx.doi.org/10.36162/hjr.v4i3.280


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